BRD7552CAS号： 1137359-47-7分子式： C33H33N3O15分子量： 711.63描述储存/保存方法外观可溶性/溶解性靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. |
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 外观 |
Off White solid
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| 可溶性/溶解性 |
DMSO,100mg/mL(140.52mM);
Ethanol,100mg/mL(140.52mM); Water,<1mg> |
| 生物活性 | |
| 靶点 |
PDX1
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| In vitro(体外研究) |
BRD7552 upregulates PDX1 expression in both primary human islets and ductal cells, and induces epigenetic changes in the PDX1 promoter consistent with transcriptional activation. BRD7552 increases PDX1 mRNA levels by 2- to 4-fold, with a maximal effect at 5 μM and the expression of MAFA. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells. Treatment of PANC-1 cells with BRD7552 causes a dose-dependent increase in insulin mRNA expression.
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分子结构图
