AG 538 is a potent, competitive inhibitor of IGF-IR (IGF-1 receptor kinase, IC₅₀ = 400 nM). Reaction is competitive with respect to IGF-1R substrate. Also inhibits the phosphorylation of PTK substrate poly(Glu,Tyr) by IGF-1R, IR, EGF-R, and Src (IC₅₀ = 60 nM, 113 nM, 370 nM, and 2.4 μM, respectively). Inhibits the phosphorylation of PKB at a much higher concentration (IC₅₀ = 76 μM).

A potent, competitive inhibitor of IGF-1 receptor kinase

≥95%

Store at -20° C

Solid

Tyrphostin AG 538

1.54 g/cm³ (Predicted)

637.48° C at 760 mmHg (Predicted)

n²⁰_D 1.75 (Predicted)

pK_a: 7.48 (Predicted)

Soluble in DMSO (5 mg/ml).

MFCD03453581

2057