2-APB is a transient receptor potential (TRP) activator. The compound also directly blocks the mitochondrial permeability transition pore, sarco/endoplasmic reticulum Ca²⁺-ATPase pumps, and native store operated channels, as well as other ion channels. 2-APB does not activate the subfamily transient receptor potential vanilloids (TRPVs) TRPV4, TRPV5, and TRPV6, but can activate VR1 (TRPV1), VRL-1 (TRPV2), and TRPV3. 2-ABP was first used as an inhibitor of IP3R (inositol 1,4,5-triphosphate receptor) with the ability to permeate the membrane. 2-ABP can induce Ca²⁺entry without activating exocytosis. In pancreatic acinar cells 2-ABP can inhibit calcium mobilization. 2-APB is an activator of Orai3.

A TRP activator that also blocks IP3R

98%

Store at -20° C，2 years.

Solid

2-氨基乙基二苯硼酸酯; 2-APB

~1.0 g/cm³ (Predicted)

101.86° C (Predicted)

~325.3° C at 760 mmHg (Predicted)

n²⁰_D 1.56 (Predicted)

Thapsigargin-induced SOCE channel: IC₅₀ = 15000 nM (fura-2 loaded human Jarkart T cells); D-myo-inositol 1,4,5-trisphosphate (IP3) receptor: IC₅₀ = 42 µM

Soluble in methanol (100 mg/ml), 95% ethanol (50 mg/ml), ethanol (10 mM), and DMSO (10 mM). Insoluble in water.

MFCD00014823

1598

2942273

208-366-5