PF-05221304CAS号： 1370448-25-1分子式： C28H30N4O5分子量： 502.56描述纯度储存/保存方法可溶性/溶解性In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
PF-05221304 is an orally active, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), a rate-limiting enzymes for fatty acid synthesis.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO:95mg/ml(189.03mM)
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| 生物活性 | |
| In vitro(体外研究) |
PF-05221304 blocked polarization of human T cells to proinflammatory but not anti-inflammatory T cells, and suppressed activation of primary human stellate cells to myofibroblasts in vitro, showing direct effects on inflammation and fibrogenesis[1].
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| In vivo(体内研究) |
PF-05221304 reduced markers of inflammation and fibrosis in the diethylnitrosamine chemical-induced liver injury model and the choline-deficient, high-fat-fed rat model[1].
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