BX-517CAS号： 850717-64-5分子式： C15H14N4O2分子量： 282.3描述纯度储存/保存方法别名可溶性/溶解性靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
BX-517 is a potent and selective inhibitor of PDK1 that binds to the ATP binding pocket of the protein (IC50 = 6 nM). |
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
BX517, BX 517
|
| 可溶性/溶解性 |
DMSO: ≥ 27 mg/mL
|
| 生物活性 | |
| 靶点 |
PDK-1
|
| In vitro(体外研究) |
BX-517 blocks activation of Akt in tumor cells, is potent with IC50 of 0.1-1.0 μM. BX-517 blocks AKT2 activation in cells with submicromolar potency. BX-517 is 100-fold selective or better against a panel of seven additional Ser/Thr and Tyr kinases.
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分子结构图
