CNS-5161 hydrochloride is a new antagonist of NMDA ion-channel. It interacts with the NMDA receptor/ion channel site to produce a noncompetitive blockade of the actions of glutamate.

98%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

DMSO:55 mg/mL (141.61 mM)

CNS-5161 has potent inhibitory activity in vitro at the NMDA ion channel and is able to displace [3H] MK-801 binding with a Ki of 1.8 nM in synaptosomal membrane preparations from rat brain.

In the neonatal rat NMDA excitotoxicity model in vivo, CNS-5161 (i.p.) protects against the necrotic effects of exogenous N-methyl-D-aspartate (ED80: 4 mg/kg). CNS-5161 also shows a 91% inhibition of audiogenic seizures in DBA/2 mice at 4 mg/kg i.p. and has a neuroprotective effect following hypoxic/ischaemic brain injury in neonatal rats[1].