PD 135158CAS号： 130325-35-8分子式： C35H44N4O6分子量： 616.76描述应用储存/保存方法形态别名密度沸点折射率光学活性IC50PK值可溶性/溶解性MDLPubChem CID
| 产品描述 | |
| 描述 |
PD 135158 is a specific and effective CCK-BR antagonist (cholecystokinin type B). CCK is a neuroendocrine peptide described to play an important role in cell growth, cell proliferation, and other biological functions. PD 135158 has been reported to show limited affinity for substance P, benzodiazepine, GABAA, neurotensin, bradykinin, and 5-HT3 binding sites.
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| 应用 |
A selective CCK-BR antagonist used for research purposes
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| 储存/保存方法 |
Store at 4° C
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| 形态 |
Solid
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| 基本信息 | |
| 别名 |
4-[[(1R)-2-[[(2R)-3-(1H-Indol-3-yl)-2-methyl-1-oxo-2-[[[[(1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl]oxy]carbonyl]amino]propyl]amino]-1-phenylethyl]amino]-4-oxobutanoic acid
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| 密度 |
1.28 g/cm3 (Predicted)
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| 沸点 |
908.8° C at 760 mmHg (Predicted)
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| 折射率 |
n20D 1.63 (Predicted)
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| 光学活性 |
α20/D -23.6°, c = 1 in acetone
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| IC50 |
CCK2: IC50 = 2.8 nM; CCK1: IC50 = 1.23 µM; 5-HT3 receptors: IC50 = > 10 µM
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| PK值 |
pKa: 4.7 (Predicted)
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| 可溶性/溶解性 |
Soluble in DMSO (100 mM).
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| MDL |
MFCD09971102
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| PubChem CID |
71433910
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