BIBB 515 is a selective and potent inhibitor of 2,3-oxidosqualene cyclase (OSC) with an ED₅₀ value of 0.2-0.5 and 0.36-33.3 mg/kg in rats and mice, respectively. Total cholesterol was reduced by 19% in normalipemic hamsters at a dose of 55 mg/kg/day for 11 days and 25% in hyperlipemic hamsters at a dose of 148 mg/kg/day for 25 days. OSC is an important enzyme in the biosynthesis of animal, fungal and plant sterols. OSC catalyzes the conversion of (3S)-2,3-oxidosqualene to lanosterol, a precursor to cholesterol, in fungi and mammals.

An OSC inhibitor

≥98%

Store at -20° C

Solid

Piperidine,1-(4-chlorobenzoyl)-4-[[4-(4,5-dihydro-2-oxazolyl)phenyl]methylene]- (9CI);BIBB 515

~1.3 g/cm³ (Predicted)

218.15° C (Predicted)

~586.5° C at 760 mmHg (Predicted)

n²⁰_D 1.63 (Predicted)

pK_b: 4.72 (Predicted)

Soluble in ethanol (~0.15 mg/ml), DMSO (5 mM), and DMF (~0.15 mg/ml).

MFCD00930515

501398