UK-5099CAS号： 56396-35-1分子式： C18H12N2O2分子量： 288.31描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
UK-5099 is an inhibitor of plasma membrane monocarboxylate transporters (MCTs) and the mitochondrial pyruvate carrier (MPC).
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| 纯度 |
>98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
PF-1005023; UK5099; UK 5099; PF1005023; PF 1005023
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| 外观 |
yellow to tan powder
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| 可溶性/溶解性 |
DMSO : ≥ 50 mg/mL (173.43 mM)
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| 生物活性 | |
| 靶点 |
mitochondrial pyruvate carrier
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| In vitro(体外研究) |
UK-5099 covalently binds to Mpc and blocks pyruvate transport. UK-5099 enhances aerobic glycolysis and decreases mitochondrial oxidative phosphorylation in LnCap cell in vitro, which is accompanied by increasing proportion of side population (SP) fraction, higher level of stemness markers expression and exhibiting high resistance to chemotherapy. UK5099 enhances stem-like phenotype of prostatic cancer cell through metabolic shift from oxidative phosphorylation to aerobic glycolysis. UK-5099 suppresses proliferation and arrested LnCap cell cycle at G1/G0.
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| In vivo(体内研究) |
UK-5099 slows the growth of patient-derived xenograft (PDX) tumors in mice without severe loss of animal body weight.
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分子结构图
