AZD7507CAS号： 1041852-85-0分子式： C23H27FN6O3分子量： 454.50描述纯度储存/保存方法别名可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
AZD7507 is a potent and orally active CSF-1R inhibitor, with antitumor activity.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
CS-2850
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| 可溶性/溶解性 |
DMSO : 130 mg/mL (286.03 mM; Need ultrasonic)
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| 生物活性 | |
| 靶点 |
CSF-1R
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| In vitro(体外研究) |
AZD7507 (Compound 31) inhibits the proliferation of 3T3 cells engineered to express CSF-1R and stimulated with CSF-1 (IC50, 32 nM), shows inhibitory activity against hERG and NaV1.5, with IC50s of >30 and 26 μM.
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| In vivo(体内研究) |
AZD7507 has good rat oral PK, with in vivo clearance of 7 mL/min/kg and 42% bioavailability. In the canine L-type Ca channel assay, the IC50 is >20 μM. AZD7507 significantly decreases the number of CD68+ macrophages in mice, and also reduces the volume and mass in mice bearing CC-LP-1 and SNU-1079 cells, but not WITT-1 cells.
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分子结构图
