Bay-K-8644 (S)-(-)- is an agonist of L-type Ca2+ channel. Bay-K-8644 (S)-(-)- activates Ba2+ currents (IBa) (EC50=32 nM).

≥98%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

Solid

Bay-K-8644 ((S)-(-)-)；(-)-BAY-R-5417；(-)-BAY-K-8644

yellow powder

1.37 g/cm³ (Predicted)

170.90° C (Predicted)

429.17° C at 760 mmHg (Predicted)

n²⁰_D 1.54 (Predicted)

α20/D -50°, c = 0.44 in 1,4-dioxane

Transient receptor potential cation channel subfamily A member 1: EC₅₀50 = 41.5 µM (mouse)

Adenosine A1 receptor: K_i= 6.66 µM (rat); Adenosine A3-R: K_i= 23.5 µM (human); Adenosine A2a receptor: K_i= 86.3 µM (rat)

DMSO : ≥ 310 mg/mL (870.05 mM)

MFCD00153769

6603728

IBa

(±)-Bay K 8644, a conventional racemic mixture of Bay K 8644, is widely used as an L-type Ca2+ channel agonist. Each optical isomer possesses opposite effects on IBa (R(+)-Bay K 8644 as an antagonist and Bay-K-8644 (S)-(-)- as an agonist. Bay-K-8644 (S)-(-)- can prevent the inhibitory actions of two distinct cyclic nucleotide pathways on IBa in gastric myocytes of the guinea pig antrum. The Ca2+ channel activity is enhanced by 3–30 μM Bay-K-8644 (S)-(-)-, an agonist of L-type Ca2+ channels. The interactions of two Ca2+ channel activators Bay-K-8644 (S)-(-)- and FPL 64176 is examined on smooth muscle L-type Ca2+ channels. FPL 64176 (300 nM) causes a sustained contraction of rat tail artery strips. This contractile response is inhibited by approximately 70% by Bay-K-8644 (S)-(-)- (EC50=14 nM). Bay-K-8644 (S)-(-)- (100 nM) increases whole-cell Ca2+ currents in A7r5 smooth muscle cells but effectively blocks further stimulation by 1 μM FPL 64176.