NS1643CAS号： 448895-37-2分子式： C15H10F6N2O3分子量： 380.25描述纯度储存/保存方法形态别名外观IC50PK值可溶性/溶解性In vitro(体外研究)
| 产品描述 | |
| 描述 |
NS1643 is a potent human ether-a-go-go related gene (hERG) KV11.1 channel activator (EC50 = 10.5 μM) |
| 纯度 |
98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 形态 |
Solid
|
| 基本信息 | |
| 别名 |
NS-1643；NS 1643
|
| 外观 |
white to off-white solid
|
| IC50 |
Activated HERG KV11.1 channel : EC5050 = 10.5 µM (human)
|
| PK值 |
pKa: 6.84 (Predicted), pKb: 1.14 (Predicted)
|
| 可溶性/溶解性 |
DMSO ：76 mg/mL (199.87 mM)
Ethanol ：76 mg/mL (199.87 mM) |
| 生物活性 | |
| In vitro(体外研究) |
NS1643 enhanced the magnitude of wild-type hERG current in a concentration- and voltage-dependent manner with an EC(50) of 10.4 microM at -10 mV.
|
分子结构图
