Human respiratory syncytial virus (HRSV) is a major respiratory viral pathogen causing moderate to severe upper and lower respiratory tract infections in all ages and across a wide range of patient populations. VP-14637 and JNJ-2408068 inhibit respiratory syncytial virus fusion by similar mechanisms by binding into a small hydrophobic cavity in the inner core of F protein, interacting simultaneously with both the HR1 and HR2 domains.

Amber Vial, Refrigerator

DMSO, THF

Andries, K., et al.: Antiviral Res., 60, 209 (2003), Douglas, J., et al.: J. Virol., 77, 5054 (2003), Cianci, C., et al.: Antimicrob. Agents Chemother., 48, 413 (2004),