Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper.¹ Capsaicin signals are transduced by a heat-activated ion channel, the vanilloid receptor 1 (VR1), or transient receptor potential vanilloid 1 (TRPV1).² CAY10448 is an iodinated nonivamide, a potent capsaicin receptor antagonist with an IC₅₀ value of approximately 10 nM.³

≥98%

Store at -20℃

1.Gannett, P.M.,Nagel, D.L.,Reilly, P.J., et al. The capsaicinoids: Their separation, synthesis, and mutagenicity. The Journal of Organic Chemistry 53(5), 1064-1071 (1988).

2.Caterina, M.J.,Schumacher, M.A.,Tominaga, M., et al. The capsaicin receptor: A heat-activated ion channel in the pain pathway. Nature 389, 816-824 (1997).

3.Daddario, N.,Minassi, A.,Appendino, G., et al. The taming of capsaicin. Synthesis and vanilloid antagonistic activity of isosteric and regioisomeric halononiv amides and their products of halogen-carbon exchange. 14th Annual Symposium on the Cannabinoids 137-137 (2004).