Prostaglandins have a short life in vivo because NAD⁺-dependent 15-hydroxy prostaglandin dehydrogenase (15-PGDH) catalyzes their oxidation to 15-keto metabolites with greatly reduced biological activity.¹ Thiazolidinediones (TZDs) are a class of PPARγ agonists that have potent 15-PGDH inhibitory activity.^2,3 CAY10638 is a TZD derivative that inhibits 15-PGDH activity with an IC₅₀ value of 31 nM.³

≥98%

Store at -20℃

Thiazolidinedione derivative;

1.Hansen, H.S. 15-Hydroxyprostaglandin dehydrogenase. A review. Prostaglandins 12, 647-679 (1976).

2.Owens, D.R. Thiazolidinediones. An pharmacological overview. Clinical Drug Investigation 22(8), 485-505 (2002).

3.Wu, Y.,Tai, H.H. and Cho, H. Synthesis and SAR of thiazolidinedione derivatives as 15-PGDH inhibitors. Bioorganic & Medicinal Chemistry 18, 1428-1433 (2010).