MIV-150 is a tight-binding, allosteric inhibitor of reverse transcriptase that is active against HIV-1 and HIV-2 (both EC₅₀s = 1 nM in vitro).¹ It has been shown to inactivate viruses that are resistant to other antiviral drugs, including non-nucleoside reverse transcriptase inhibitors, nucleoside reverse transcriptase inhibitors, and protease inhibitors.¹ Although MIV-150 possesses poor oral bioavailability, it demonstrates efficacy when formulated as a topical microbicide.^2,3

≥98%

Store at -20℃

PC-815;

1.Fernández-Romero, J.A.,Thorn, M.,Turville, S.G., et al. Carrageenan/MIV-150 (PC-815), a combination microbicide. Sex.Transm.Dis. 34(1), 9-14 (2007).

2.Turville, S.G.,Aravantinou, M.,Miller, T., et al. Efficacy of Carraguardr-based microbicides in vivo despite variable in vitro activity. PLoS One 3(9), e3162 (2008).

3.Singer, R.,Derby, N.,Rodriguez, A., et al. The nonnucleoside reverse transcriptase inhibitor MIV-150 in carrageenan gel prevents rectal transmission of simian/human immunodeficiency virus infection in macaques. Journal of Virology 85(11), 5504-5512 (2011).