UR-144 (Item No. 11502) is a potent synthetic cannabinoid (CB) which preferentially binds the peripheral CB₂ receptor (K_i = 1.8 nM) over the central CB₁ receptor (K_i = 150 nM).¹ UR-144 N-(5-bromopentyl) analog differs from UR-144 by having a bromine atom on the terminal carbon of the alkyl group. While similar modifications have little effect on the receptor affinities of analogs of tetrahydrocannabinol, the activity of this compound has not been examined.^2,3 This product is intended for research and forensic applications.

≥98%

Store at -20℃

5-bromo UR-144;

1.Frost, J.M.,Dart, M.J.,Tietje, K.R., et al. Indol-3-ylcycloalkyl ketones: Effects of N1 substituted indole side chain variations on CB₂ cannabinoid receptor activity. Journal of Medicinal Chemistry 53, 295-315 (2010).

2.Nikas, S.P.,Grzybowska, J.,Papahatjis, D.P., et al. The role of halogen substitution in classical cannabinoids: A CB₁ pharmacophore model. AAPS Journal 6(4), 1-13 (2004).

3.Nikas, S.P.,Alapafuja, S.O.,Papanastasiou, I., et al. Novel 1′,1′-chain substituted hexahydrocannabinols: 9β-hydroxy-3-(1-hexyl-cyclobut-1-yl)-hexahydrocannabinol (AM2389) a highly potent cannabinoid receptor 1 (CB₁) agonist. Journal of Medicinal Chemistry 53, 6996-7010 (2010).