ZK 93423 hydrochloride is a potent benzodiazepine agonist. Non-selective with GABA_A receptors containing α1-, α2-, α3- and α5-subunits.

98%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

Solid

4-(Methoxymethyl)-6-(phenylmethoxy)-9H-pyrido[3,4-b]indole-3-carboxylic acid ethyl ester hydrochloride

Yellow solid

Soluble to 30 mM in DMSO and to 5 mM in Ethanol

56972166

The full agonist ZK-93423 is not subtype selective and stimulates α1, α2, α3, and α5-subunit containing GABAA receptors equally [α1β32 (Ki = 4.1 nM), α2β32 (Ki = 4.2 nM), α3β32 (Ki = 6.0 nM), α5β32 (Ki = 4.5 nM), α6β32 (Ki >1000 nM). ZK-93423 has also been used as a base to develop new and improved beta-carboline derivatives and help map the binding site of the GABAA receptor. In rats trained to discriminate PTZ from saline, the PTZ cue was antagonized by ZK 93423, which indicated ZK 93423 may exhibit anxiolytic quality .

ZK 93423 showd to have anxiolytic properties on animal models of anxiety, including social interaction, vogel, geller serfter, 4-plate test and elevated plus-maze. The anxiogenic and anxiolytic actions are mediated by the BDZ binding sites .