ZK 200775CAS号： 161605-73-8分子式： C14H15N3O6F3P分子量： 409.25描述应用储存/保存方法形态别名密度熔点沸点折射率PK值Ki 数据可溶性/溶解性MDLPubChem CID
| 产品描述 | |
| 描述 |
ZK 200775 is a competitive GluR (AMPA)/kainate antagonist. In rat cortical membranes, it displays high affinity for [3H]-AMPA (Ki = 120 nM) and [3H]-CNQX (Ki = 32 nM) binding sites but low affinity for kainate and NMDA channel-associated binding sites (IC50 values range from 2.5 to 11 μM). It inhibits currents induced by AMPA, kainate and NMDA with IC50 values of 21 nM, 27 nM, and > 1 μM respectively. AMPA is a transmembrane glutamate receptor composed of the subunits GluR-1,2,3,4.
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| 应用 |
A competitive AMPA/kainate antagonist
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| 储存/保存方法 |
Desiccate at 4° C
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| 形态 |
Solid
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| 基本信息 | |
| 别名 |
MPQX
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| 密度 |
1.62 g/cm3 (Predicted)
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| 熔点 |
90.27° C (Predicted)
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| 沸点 |
480.00° C (Predicted)
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| 折射率 |
n20D 1.56 (Predicted)
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| PK值 |
pKa: 1.44 (Predicted), pKb: 2.8 (Predicted)
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| Ki 数据 |
[3H]-CNQX: Ki= 32 nM (rat cortical membranes); [3H]-AMPA : Ki= 120 nM (rat cortical membranes); DCKA binding site: Ki= 2.8 µM
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| 可溶性/溶解性 |
Soluble in DMSO (100 mM), and ethanol (50 mM).
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| MDL |
MFCD07364000
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| PubChem CID |
208953
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