GSK2795039CAS号： 1415925-18-6分子式： C23H26N6O2S分子量： 450.56描述纯度储存/保存方法别名可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
GSK2795039 is a NADPH oxidase 2 inhibitor with a mean pIC50 of 6 in different cell-free assays.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
GSK-2795039
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| 可溶性/溶解性 |
DMSO : 100 mg/mL (221.95 mM; Need ultrasonic)
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| 生物活性 | |
| 靶点 |
NOX2；NADPH； ROS
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| In vitro(体外研究) |
GSK2795039 inhibits both the formation of ROS and the utilization of the enzyme substrates, NADPH and oxygen, in a variety of semirecombinant cell-free and cell-based NOX2 assays. GSK2795039 inhibits NOX2 in an NADPH competitive manner and is selective over other NOX isoforms, xanthine oxidase, and endothelial nitric oxide synthase enzymes.
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| In vivo(体内研究) |
Following systemic administration in mice, GSK2795039 abolishes the production of ROS by activated NOX2 enzyme in a paw inflammation model. GSK2795039 shows activity in a murine model of acute pancreatitis, reducing the levels of serum amylase triggered by systemic injection of cerulein.
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分子结构图
