CAY10786CAS号： 1239987-91-7分子式： C15H14OS分子量： 242.34描述储存/保存方法可溶性/溶解性In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
CAY10786 is an antagonist of G protein-coupled receptor 52 (GPR52, IC50 = 0.63 μM).
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO:245 mg/mL (1010.98 mM)
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| 生物活性 | |
| In vitro(体外研究) |
CAY10786 reduces mutant huntingtin (mHTT) protein levels in STHdhQ7/Q111cells in a concentration-dependent manner. CAY10786 (3 μM) reduces apoptosis induced by growth factor deprivation in primary striatal neurons[1].
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| In vivo(体内研究) |
In the homozygous HdhQ140 mouse model of Huntington’s disease, CAY10786 (5 mg/kg) increases the latency to fall in the rotarod test and decreases striatal levels of soluble and insoluble mHTT[1].
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