FTY720 (R)-Phosphate, FTY720 is a novel immune modulator that inhibits lymphocyte emigration from lymphoid organs, which prolongs allograft transplant survival in numerous models. Sphingosine kinases phosphorylate FTYS20 in vivo so that FTYS20 acts as a potent agonist at four of the five sphingosine-1-phosphate (S1P) receptors . FTY720 (R)-phosphate is one stereoisomer of FTY720-phosphate, but it is evidently not formed in vivo. FTY720 (S)-phosphate exhibits K_i values of 2.1, 5.9, 23, and 2.2 nM for S1P1,3,4,5, respectively, while the R isomer binds with 5-130-fold lower affinity.

An immunomodulator & inhibitor of lymphocyte emigration as well as a S1P agonist

≥98%

Store at -20° C

Solid

~1.2 g/cm³ (Predicted)

90.27° C (Predicted)

~584.2° C at 760 mmHg (Predicted)

n²⁰_D 1.54 (Predicted)

EDG-1: EC₅₀50 = 0.14 nM (human); EDG-1: IC₅₀ = 0.16 nM (human); EDG-8: EC₅₀50 = 0.46 nM (human); EDG-6: EC₅₀50 = 0.7 nM (human); EDG-5: IC₅₀ >22 µM (human)

pK_a: 1.73 (Predicted), pK_b: 10.04 (Predicted)

Soluble in chloroform (~0.5 mg/ml).

MFCD18427927

11222939