FTY720 (R)-PhosphateCAS号: 402616-23-3分子式: C19H34NO5P分子量: 387.5描述应用纯度储存/保存方法形态密度熔点沸点折射率IC50PK值可溶性/溶解性MDLPubChem CID
产品描述 | |
描述 |
FTY720 (R)-Phosphate, FTY720 is a novel immune modulator that inhibits lymphocyte emigration from lymphoid organs, which prolongs allograft transplant survival in numerous models. Sphingosine kinases phosphorylate FTYS20 in vivo so that FTYS20 acts as a potent agonist at four of the five sphingosine-1-phosphate (S1P) receptors . FTY720 (R)-phosphate is one stereoisomer of FTY720-phosphate, but it is evidently not formed in vivo. FTY720 (S)-phosphate exhibits Ki values of 2.1, 5.9, 23, and 2.2 nM for S1P1,3,4,5, respectively, while the R isomer binds with 5-130-fold lower affinity.
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应用 |
An immunomodulator & inhibitor of lymphocyte emigration as well as a S1P agonist
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纯度 |
≥98%
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储存/保存方法 |
Store at -20° C
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形态 |
Solid
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基本信息 | |
密度 |
~1.2 g/cm3 (Predicted)
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熔点 |
90.27° C (Predicted)
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沸点 |
~584.2° C at 760 mmHg (Predicted)
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折射率 |
n20D 1.54 (Predicted)
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IC50 |
EDG-1: EC5050 = 0.14 nM (human); EDG-1: IC50 = 0.16 nM (human); EDG-8: EC5050 = 0.46 nM (human); EDG-6: EC5050 = 0.7 nM (human); EDG-5: IC50 >22 µM (human)
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PK值 |
pKa: 1.73 (Predicted), pKb: 10.04 (Predicted)
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可溶性/溶解性 |
Soluble in chloroform (~0.5 mg/ml).
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MDL |
MFCD18427927
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PubChem CID |
11222939
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