CAY10719 is a selective inhibitor of the breast cancer resistance protein ABCG2 (IC₅₀ = 0.23 µM) with little activity at ABCG1.¹ It has been shown to reverse the ABCG2-mediated resistance toward SN 38 (Item No. 15632) and to inhibit ATPase activity.¹

≥98%

Store at -20℃

1.Spindler, A.,Stefan, K. and Wiese, M. Synthesis and investigation of tetrahydro-β-carboline derivatives as inhibitors of the breast cancer resistance protein (ABCG2). J.Med.Chem. 59(13), 6121-6135 (2016).