CAY10701 is a 7-deazahypoxanthine analog that prevents microtubule formation, blocking the proliferation of HeLa and MCF-7 cells (GI₅₀s = 22 and 38 nM, respectively).¹ It also inhibits the growth of several different colorectal cancer cell lines (GI₅₀ values range from 9 to 17 nM), while being at least 1,500-fold less effective against normal human fibroblast WI38 cells.¹ CAY10701 is effective in vivo, reducing tumor volume in colorectal cell xenografts in mice without significantly altering body weight.¹

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1.Medellin, D.C.,Zhu, Q.,Scott, R., et al. Novel microtubule-targeting 7-deazahypoxanthines derived from marine alkaloid rigidins with potent in vitro and in vivo anticancer activities. J. Med. Chem. 59, 480-485 (2016).