CAY10654CAS号: 1298023-69-4分子式: C17H25ClN2O3分子量: 340.9描述纯度储存/保存方法参考文献
产品描述 | |
描述 |
The gram-negative pathogen Pseudomonas aeruginosa uses N-acylated-L-homoserine lactones (AHLs) in quorum sensing to modulate transcriptional activators, including LasR, and regulate the expression of virulence factors. The same AHLs suppress the host immune system. CAY10654 is a synthetic analog of natural AHLs that suppresses host immunity without inducing LasR.1 It inhibits the proliferation of mouse peripheral blood leukocytes by concanavalin A (EC50 = 9.3 μM) without concurrent cytotoxicity.1 LasR is not induced by 100 μM CAY10654, although LasR is potently induced by natural AHL (5 μM) in positive control experiments.1
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纯度 |
≥98%
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储存/保存方法 |
Store at -20℃
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参考文献 | |
参考文献 |
1.Jadhav, G.P.,Chhabra, S.R.,Telford, G., et al. Immunosuppressive but non-LasR-inducing analogues of the Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone. Journal of Medicinal Chemistry 54(9), 3348-3359 (2011).
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分子结构图