Prostaglandin D₂ (PGD₂) evokes its effects through two receptors, DP₁ and CRTH2/DP₂. The activation of DP₂ leads to eosinophil chemotaxis, activation, and degranulation as well as recruitment of basophils and lymphocytes and, as a result, is important in allergic inflammatory disease. CAY10648 is an intermediate used in the synthesis of potent DP₂ receptor antagonists based on a novel spiro-indolinone compound.¹

≥98%

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1.Crosignani, S.,Page, P.,Missotten, M., et al. Discovery of a new class of potent, selective, and orally bioavailable CRTH2 (DP₂) receptor antagonists for the treatment of allergic inflammatory diseases. Journal of Medicinal Chemistry 51, 2227-2243 (2008).