Very long chain polyunsaturated fatty acids (VLCPUFA) are present in retina, sperm, and brain.^1,2,3 Though little is known of their biosynthesis or functional roles in these tissues, recent studies using the elongation of very long-chain FA-4 protein suggest a unique role for VLCPUFA in retinal development and macular degeneration.^4,5 CAY10632 is a C₃₂:6 VLCPUFA whose specific biological actions are largely unknown, but are thought to involve normal photoreceptor cell function in the retina.^4,6

≥98%

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1.Aveldaño, M.I. Phospholipid species containing long and very long polyenoic fatty acids remain with rhodopsin after hexane extraction of photoreceptor membranes. Biochemistry 27, 1229-1239 (1988).

2.Robinson, B.S.,Johnson, D.W. and Poulos, A. Novel molecular species of spingomyelin containing 2-hydroxylated polyenoic very-long-chain fatty acids in mammalian testes and spermatozoa. The Journal of Biological Chemisty 267, 1746-1751 (1992).

3.Robinson, B.S.,Johnson, D.W. and Poulos, A. Unique molecular species of phophatidylcholine containing very-long-chain (C₂₄-C₃₈) polyenoic fatty acids in rat brain. Biochemistry Journal 265, 763-767 (1990).

4.McMahon, A.,Jackson, S.N.,Woods, A.S., et al. A Stargardt disease-3 mutation in the mouse Elovl4 gene causes retinal deficiency of C₃₂-C₃₆ acyl phosphatidylcholines. FEBS Letters 581, 5459-5463 (2007).

5.Agbaga, M.P.,Mandal, M.N.A. and Anderson, R.E. Retinal very long-chain PUFAs: New insights from studies on ELOVL4 protein. Journal of Lipid Research 51, 1624-1642 (2010).

6.Agbada, M.P.,Brush, R.S.,Mandal, N.A., et al. Role of Stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis of very long chain fatty acids. Proceedings of the National Academy of Sciences of the United States of America 105(35), 12843-12848 (2008).