The α₁-adrenergic receptors are G_q protein-coupled receptors that play a key role in the modulation of sympathetic nervous system activity and are the site of action for therapeutic agents, such as antihypertensive drugs. A-61603 is a selective α_1A-adrenergic receptor agonist that is at least 35-fold more potent at α_1A receptor sites than at α_1B or α_1D. Activation of the α_1A-adrenergic receptor by A-61603 has been reported to increase the frequency of spontaneous Ca²⁺ transients in rat ventricular myocytes in vitro (EC₅₀ = 6.9 nM) much more potently than activation by phenylephrine (Item No. 17205; EC₅₀ = 2.3 µM).

≥98%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

crystalline solid

Soluble in H2O

1.Meyer, M.D.,Altenbach, R.J.,Hancock, A.A., et al. Synthesis and in vitro characterization of N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8- tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: A novel selective α1A receptor agonist. Journal of Medicinal Chemistry 39(20), 4116-4119 (1996).

2.Luo, D.l.,Gao, J.,Fan, L.l., et al. Receptor subtype involved in α₁-adrenergic receptor-mediated Ca²⁺ signaling in cardiomyocytes. Acta.Pharmacol.Sin. 28(7), 968-974 (2007).