CAY10592 is a peroxisome proliferator-activated receptor (PPAR) β agonist. PPARs are ligand-activated nuclear transcription factors involved in the regulation of energy homeostasis as well as insulin sensitivity and glucose metabolism . Pharmacologies of PPARβ receptor agonists, though relatively unknown, have recently been reported to elevate lower plasma triglyceride (TG) and high-density lipoprotein (HDL) cholesterol levels. CAY10592 is a full PPARβ agonist (EC₅₀ = 30 nM) in a fatty acid oxidation assay of rat L6 muscle cells. In a transactivation assay using human PPAR receptors, CAY10592 acts as a selective partial PPARβ agonist (EC₅₀ = 53 nM) with no effect on PPARγ or PPARα activity up to 30 µM.

A full PPARγ agonist

Store at -20° C

2-[4-[[3,3-bis(4-bromophenyl)-2-propen-1-yl]thio]-2-chlorophenoxy]-acetic acid

A crystalline solid