5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-[[4-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarboxamide is a potent benzimidazole analog that inhibits IKK-ε with an IC₅₀ value of ~15.8 μM (1), where IKK-ε is mostly expressed n immune cells and thought to play a role in immune response.

A benzimidazole analog and IKK inhibitor

≥95%

Store at -20° C

Solid

1.46 g/cm³ (Predicted)

735.37° C at 760 mmHg (Predicted)

n²⁰_D 1.67 (Predicted)

Plk: IC₅₀ = 75 nM (human); IKK-ε: IC₅₀ ~15.8 µM; HCT-116: IC₅₀ >30 µM (human)

pK_b: 3.39 (Predicted)

Soluble in DMSO (~10 mg/ml), DMF (~1 mg/ml), and DMSO: PBS(pH7.2) (1:4) (~0.2 mg/ml).

MFCD10567699

25190912