BM 567 is a dual acting antithrombogenic agent, acting as an inhibitor of TXA2 synthase and as an antagonist of the TXA2R (TP receptor), the G protein-coupled receptor mediating TXA2 activity in platelets and vascular smooth muscle. It also antagonizes the vascular smooth muscle TP receptor with an IC50 value of 1.1 nM. BM 567 is an inhibitor of platelet TX synthase with an IC50 value of 12 nM.Thromboxane A2 (TXA2) is a potent thrombogenic and vasoconstrictor eicosanoid, produced in large amounts by activated platelets. TXA2 has been found to be a causal factor in the onset of stroke and myocardial infarction.

A potent thrombogenic and vasoconstrictor eicosanoid

>98%

Store at -20° C

Solid

~1.3 g/cm³ (Predicted)

253.11° C (Predicted)

586.72° C (Predicted)

n²⁰_D 1.57 (Predicted)

Vascular smooth muscle TP receptor : IC₅₀ = 1.1 nM; TXA2R: IC₅₀ = 1.1 nM (human); Platelet TX synthase: IC₅₀ = 12 nM

pK_a: 4.56 (Predicted)

Soluble in water (0.5 mg/ml at 25° C), ethanol (~10 mg/ml), DMSO (~20 mg/ml), DMF (~20 mg/ml), and DMSO:PBS (pH 7.2) (1:1) (~0.5 mg/ml).

MFCD08062219

9866368