CAY10640CAS号: 1208549-68-1分子式: C17H20F3N3O3分子量: 371.4描述纯度储存/保存方法别名参考文献
产品描述 | |
描述 |
Soluble epoxide hydrolase (sEH) inhibitors have important therapeutic use by increasing the in vivo concentration of EETs and other fatty acid epoxides, resulting in anti-inflammatory, antihypertensive, neuroprotective, and cardioprotective effects. CAY10640 is a 1-aryl-3-(1-acylpiperidin-4-yl)urea analog that inhibits recombinant human and mouse sEH with IC50 values both equal to 0.4 nM.1 CAY10640 demonstrates a 1,000-fold increase in potency compared to morphine in reducing hyperalgesia in an in vivo carrageenan-induced inflammatory pain model.1
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纯度 |
≥98%
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储存/保存方法 |
Store at -20℃
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基本信息 | |
别名 |
sEHi;Soluble Epoxide Hydrolase Inhibitor;
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参考文献 | |
参考文献 |
1.Rose, T.E.,Morisseau, C.,Liu, J.Y., et al. 1-aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: Structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain. Journal of Medicinal Chemistry (2010).
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分子结构图