Eg5 Inhibitor IV, VS-83 is a cell-permeable Monastrol analog with enhanced potency and selectivity (over 8 other kinesins) in inhibiting mitotic kinesin Eg5-ATPase activity (IC₅₀ = 1.17 vs. 20.73 μM for VS-83 and Monastrol, respectively) and in inducing monoasters formation (EC₅₀ = 7.27 vs. 58.74 μM for BSC-1 cells treated with VS-83 and Monastrol, respectively). Exhibits ≥10-fold antiproliferative activity than Monastrol against U-87 MG, U-118 MG, and U-373 MG glioblastoma cells.

An inhibitor of mitotic kinesin Eg5-ATPase activity

≥99%

Store at -20° C

Solid

1.47 g/cm³ (Predicted)

195.27° C (Predicted)

379.66° C at 760 mmHg (Predicted)

n²⁰_D 1.73 (Predicted)

VS-83: IC₅₀ = 1.17 µM; Monastrol: IC₅₀ = 20.73 µM; BSC-1 cells treated with VS-83: EC₅₀50 = 7.27 µM; BSC-1 cells treated with Monastrol: EC₅₀50 = 58.74 µM

Soluble in DMSO (50 mg/ml), and ethanol (5 mg/ml).

11521919