NMS-P715 analogCAS号： 1202055-34-2分子式： C35H42N8O3分子量： 622.76描述纯度储存/保存方法别名可溶性/溶解性靶点In vitro(体外研究)参考文献
| 产品描述 | |
| 描述 |
NMS-P715 analog是NMS-P715的类似物，NMS-P715是首个高效、ATP竞争性Mps1抑制剂（IC50值为8nM）。 |
| 纯度 |
98% min
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
NMS P715 analog; NMS-P 715 analog
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| 可溶性/溶解性 |
10 mM in DMSO
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| 生物活性 | |
| 靶点 |
Mps1
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| In vitro(体外研究) |
NMS-P715 analog (Compound 14) is an inhibitor of MPS1, with an IC50 of 84 nM; also less active on Aur-A, CDK2/A and PLK1 (IC50, 1.45, >10, 0.237 μM). In addition, NMS-P715 analog shows inhibitory effect on human tumor cell line (A2780) with an IC50 of 150 nM.
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| 参考文献 | |
| 参考文献 |
[1]. Colombo R, et al. Targeting the mitotic checkpoint for cancer therapy with NMS-P715, an inhibitor of MPS1 kinase. Cancer Res. 2010 Dec 15;70(24):10255-64.
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分子结构图
