CHS-828CAS号： 200484-11-3分子式： C19H22ClN5O分子量： 371.87描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
CHS-828 is a pyridyl cyanoguanidine anti-tumor agent that has been identified as a competitive inhibitor of Nampt as well as an inhibitor of NF-κB pathway activity.
|
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
CHS828,CHS 828
|
| 外观 |
Powder
|
| 可溶性/溶解性 |
DMSO 74 mg/mL (198.99 mM)
*溶解度仅供参考 |
| 生物活性 | |
| 靶点 |
NAMPT,NAMPT
|
| In vitro(体外研究) |
GMX1778 induces NAD+ depletion through inhibition of NAD+ biosynthesis, followed by ATP depletion and ultimately resulted in cell death. GMX1778 induces programmed cell death with apoptotic features. GMX1778 suppresses nuclear factor-kappa B activity in cancer cells through downregulation of IKK activity (IC50=8 nM).
|
| In vivo(体内研究) |
GMX1778 (250 mg/kg, p.o.) shows marked antitumoural activity against three different human neuroendocrine tumours, midgut carcinoid (GOT1), pancreatic carcinoid (BON), and medullary thyroid carcinoma (GOT2), transplanted in nude mice.
|
分子结构图
