NVP-BAG956CAS号： 853910-02-8分子式： C28H21N5分子量： 427.50描述纯度储存/保存方法形态别名外观可溶性/溶解性靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
NVP-BAG956 is an ATP-competitive PI3K inhibitor with IC50s of 34, 56, 112 and 444 nM for PI3Kδ, PI3Kα, PI3Kγ and PI3Kβ, respectively.
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| 纯度 |
≥98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 形态 |
Solid
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| 基本信息 | |
| 别名 |
NVP-BAG956
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| 外观 |
Red solid
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| 可溶性/溶解性 |
Soluble in DMSO (40 mM), and ethanol (20 mM).
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| 生物活性 | |
| 靶点 |
PI3Kδ,PI3Kα,PI3Kγ,PI3Kβ,PDK1,VEGFR1
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| In vitro(体外研究) |
NVP-BAG956 also inhibits PDK1 with an IC50 of 240/260 nM. NVP-BAG956 also inhibits VEGFR1 with an IC50 of 2.56±0.56 μM. NVP-BAG956 blocks phosphorylation of PKB/Akt in A2058 cells with an IC50 value of 67±25 nM. Inhibition of PKB/Akt phosphorylation correlated with loss of A2058 cell proliferation for NVP-BAG956 (IC50=290±20 nM). In the presence of NVP-BAG956, A2058 cells are only able to exit G2-M and then remain in G1. The p27Kip1 expression is clearly induced by NVP-BAG956 in A2058 cells but not in C32 cells.
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分子结构图
