JZP-361CAS号: 1680193-80-9分子式: C22H20ClN5O分子量: 405.88描述纯度储存/保存方法可溶性/溶解性靶点In vitro(体外研究)
产品描述 | |
描述 |
JZP-361 is a specific MAGL inhibitor with IC50s of 46 nM, 7.24 μM, and 1.79 μM for human recombinant MAGL, human recombinant FAAH, and human hABHD6. JZP-361 displays anti-histaminergic activities. JZP-361 can be used in studies about asthma.
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纯度 |
98%
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储存/保存方法 |
Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
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基本信息 | |
可溶性/溶解性 |
DMSO:7.3 mg/mL (18.0 mM)
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生物活性 | |
靶点 |
hABHD6:1.79 μM, hFAAH:7.24 μM, H1 Receptor:6.81 (pA2), hMAGL:46 nM
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In vitro(体外研究) |
JZP-361 shows the affinity of H1 antagonistic with a pA2 of 6.81). JZP-361(≤10 μM) does not show cannabinoid receptor activity. JZP-361 displays favorable interactions within the important hydrogen-bonding of the carbonyl oxygen to the oxyanion hole[1].
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