PentostatinCAS号： 53910-25-1分子式： C11H16N4O4分子量： 268.27描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vivo(体内研究)
| 产品描述 | |
| 描述 |
Pentostatin(Deoxycoformycin)是不可逆的腺苷脱氨酶抑制剂，Ki为2.5 pM。 |
| 纯度 |
＞98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
喷司他丁；CI-825；Deoxycoformycin
|
| 外观 |
白色至类白色固体
|
| 可溶性/溶解性 |
DMSO : ≥ 50 mg/mL (186.38 mM)
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| 生物活性 | |
| 靶点 |
Adenosine Deaminase
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| In vivo(体内研究) |
In ECP and Pentostatin (4 mg/m2, i.v.) treatment, all dogs develop granulocytopenia with . Pentostatin (2 mg/kg) in combination with cordycepin (2 mg/kg) is 100% effective in the T. evansi-infected mice. There is an increase in levels of some biochemical parameters, especially on liver enzymes, which are accompanied by histological lesions in the liver and kidneys. Pentostatin individually has no curative effect on infected groups.
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分子结构图
