SM-6586 is a potent calcium channel antagonist with inhibitory effects on Na+/H+ and Na+/Ca2+ exchange channels, and can be used in the study of cerebrovascular disease and hypertension, among other diseases.

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

In spontaneously hypertensive rats treated with SM-6586, the survival rate after bilateral common carotid artery ligation is higher, the brain water content is lower, and the ATP level is higher, while lactate level is decreased. In focal ischemia models, the SM-treated group shows a reduction of T1 relaxation time. Additionally, the brain water content is significantly decreased in the SM-treated group[1].