Rabbit anti-MonoMethyl-UHRF1-K385 Polyclonal Antibody别名宿主反应种属应用分子量免疫原纯化方法类型同种型存储溶液背景说明UniProt
| 概述 | |
| 别名 |
MonoMethyl-UHRF1-K385抗体;UHRF1; ICBP90; Np95; RNF106; TDRD22; hNP95; hUHRF1; huNp95
|
| 宿主 |
Rabbit
|
| 反应种属 |
Human,Mouse,Rat
|
| 应用 |
WB 1:500 – 1:2000
IHC 1:50 – 1:200 IF 1:50 – 1:200 |
| 分子量 |
Detects a band of approximately 91kD (Predicted molecular weight: 89kD/91kD)
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
| 免疫原 |
A synthetic monomethylated peptide around K385 of human UHRF1 (NP_001041666.1).
|
| 性能 | |
| 纯化方法 |
Affinity purification
|
| 类型 |
Polyclonal Antibody
|
| 同种型 |
IgG
|
| 存储溶液 |
Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
|
| 靶标 | |
| 背景说明 |
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.
|
| UniProt |
Q96T88
|