LJI-308CAS号： 1627709-94-7分子式： C21H18F2N2O2分子量： 368.38描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
LJI308 is a selective and potent RSK inhibitor.
|
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
LJI 308，LJI308
|
| 外观 |
Powder
|
| 可溶性/溶解性 |
DMSO: ≥ 32 mg/mL
|
| 生物活性 | |
| 靶点 |
RSK2,RSK1,RSK3
|
| In vitro(体外研究) |
In MDA-MB-231 and H358 cells, LJI308 blocks cellular inhibition of RSK and its phosphorylation of YB1 on Ser102 with EC50 of 0.2–0.3 μM, and thus inhibits cell growth. In TNBC HTRY-LT cells, LJI308 also suppresses cell growth correlative with YB-1 inhibition.
|
分子结构图
